Advancements in mass spectrometry-based glycoproteomics and glycomics
نویسندگان
چکیده
منابع مشابه
Glycomics Using Mass Spectrometry
Mass spectrometry (MS), which has advanced rapidly in recent years, is expected to become the tool of choice for high-throughput analysis of relationships between structures and functions of glycans. The structural analysis of glycans using MS employs a number of methods for pretreatment, derivatization, and interpretation. However, since none of these are universally applicable, researchers ha...
متن کاملMass spectrometry based glycoproteomics--from a proteomics perspective.
Glycosylation is one of the most important and common forms of protein post-translational modification that is involved in many physiological functions and biological pathways. Altered glycosylation has been associated with a variety of diseases, including cancer, inflammatory and degenerative diseases. Glycoproteins are becoming important targets for the development of biomarkers for disease d...
متن کاملGlycoproteomics based on tandem mass spectrometry of glycopeptides.
Next to the identification of proteins and the determination of their expression levels, the analysis of post-translational modifications (PTM) is becoming an increasingly important aspect in proteomics. Here, we review mass spectrometric (MS) techniques for the study of protein glycosylation at the glycopeptide level. Enrichment and separation techniques for glycoproteins and glycopeptides fro...
متن کاملMass Spectrometry-Based N-Glycomics of Colorectal Cancer
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation. Recent advances in mass spectrometry and bioinformatics ha...
متن کاملGlycomics and Glycoproteomics Databases in Japan and Asia
The ‘‘Integrated Database Project’’ was initiated to establish a publically accessible database to integrate all useful life science databases in Japan. Our JCGGDB (Japan Consortium for Glycobiology and Glycotechnology Database) was selected as a promotion program in the project, focussing on the integration of all the glycan-related databases and establishment of user-friendly search systems. ...
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ژورنال
عنوان ژورنال: National Science Review
سال: 2016
ISSN: 2053-714X,2095-5138
DOI: 10.1093/nsr/nww019